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Some clinicians are prescribing tirzepatide to breastfeeding mothers based on its molecular similarity to GLP-1, its large molecular weight (which reduces breast milk transfer), and the favorable animal data

doi: 10.1093/aje/kwv254 [DOI] [PMC free article] [PubMed] [Google Scholar] 14.Lund JL, Richardson DB, Strmer T

(2021) 106:e1420e32

The result, in preclinical and early clinical data, is maintained blood sugar regulation with reduced nausea and vomiting

Fourth, an important issue that is often raised is whether any GLP-1RAs can indeed penetrate the bloodbrain barrier and therefore express any neurobiological activity in the CNS, which would result in cognitive or behavioral changes